Messenger RNA delivery by hydrazone-activated polymers

Development of Delivery Strategies Facilitating Broad Application of Messenger Rna Tumor Vaccine by Development of Delivery Strategies Facilitating Broad Application of Messenger Rna Tumor Vaccine By

Genetic modification of dendritic cells with plasmid DNA is plagued with low transfection efficiencies because DNA taken up by non-dividing dendritic cells rarely reaches the nucleus. But this difficulty can be overcome by the use of messenger RNA (mRNA), which exerts its biological function in the cytoplasm and obviates the need to enter the nucleus. Since pioneering work of Boczkwoski et al.,...

Messenger RNA.

Intracellular delivery of messenger RNA by recombinant PP7 virus-like particles carrying low molecular weight protamine

BACKGROUND Cell-penetrating peptides (CPPs) have been widely used as carriers to transport different molecules into living cells, whereas messenger RNAs (mRNAs) have been utilized as target molecules for the prevention and treatment of various diseases. However, the instability of CPPs and mRNAs has limited their application. Bacteriophage PP7 virus-like particles (VLPs) may protect peptides an...

Messenger RNA Modulated by Thioacetamide Increased Activity of Rat Liver Messenger RNA and of Albumin

Administration of thioacetamide to rats was found to increase the activity of liver messenger RNA in the wheat germ protein synthesis assay. The synthesis of total protein was increased about 2.5-fold after 4 days of treatment. The treatment was associated with an increase in the relative quantity of polyadenylic acid-containing RNA. Immunoprecipitation studies showed that albumin synthesis dir...

Increased activity of rat liver messenger RNA and of albumin messenger RNA modulated by thioacetamide.

Administration of thioacetamide to rats was found to increase the activity of liver messenger RNA in the wheat germ protein synthesis assay. The synthesis of total protein was increased about 2.5-fold after 4 days of treatment. The treatment was associated with an increase in the relative quantity of polyadenylic acid-containing RNA. Immunoprecipitation studies showed that albumin synthesis dir...